Overview

Scientific breakthroughs often come on the heels of technological advances; advances that expose hidden truths of nature, and provide tools for engineering the world around us. Examples include the telescope (heliocentrism), the Michelson interferometer (relativity) and recombinant DNA (molecular evolution). Our lab explores innovative experimental approaches to problems in molecular biochemistry, focusing on technologies with the potential for broad impact.

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Selected Publications

Structural and kinetic mapping of side-chain exposure onto the protein energy landscape.
Bernstein R, Schmidt KL, Harbury PB, Marqusee S
Proc. Natl. Acad. Sci. U.S.A. 108: 10532-7 (2011)
PDF | PubMED

The equilibrium unfolding pathway of a (beta/alpha)8 barrel.
Silverman JA, Harbury PB
J. Mol. Biol. 324: 1031-40 (2002)
PDF | PubMED

Selected Publications

Mesofluidic devices for DNA-programmed combinatorial chemistry.
Weisinger RM, Marinelli RJ, Wrenn SJ, Harbury PB
PLoS ONE 7: e32299 (2012)
PDF | PubMED

Highly parallel translation of DNA sequences into small molecules.
Weisinger RM, Wrenn SJ, Harbury PB
PLoS ONE 7: e28056 (2012)
PDF | PubMED

selected Publications

Structural ensemble and microscopic elasticity of freely diffusing DNA by direct measurement of fluctuations.
Shi X, Herschlag D, Harbury PA
Proc. Natl. Acad. Sci. U.S.A. 110: E1444-51 (2013)
PDF | PubMED

Remeasuring the double helix.
Mathew-Fenn RS, Das R, Harbury PA
Science 322: 446-9 (2008)
PDF | PubMED